ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) will improve the level or impact of ergotamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Acute ergot toxicity characterised by vasospasm and tissue ischemia has been connected with coadministration of ritonavir
dronedarone will boost the degree or result of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
B: Could be suitable. Either animal scientific studies present no risk but human experiments not out there or animal scientific tests confirmed minor threats and human experiments completed and showed no hazard.
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ergotamine will improve the level or result of tinidazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
Really serious and/or daily life-threatening peripheral ischemia connected to coadministration of ergotamine and caffeine with potent CYP3A4 inhibitors together with protease inhibitors and macrolide antibiotics
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istradefylline will increase the stage or result of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
eluxadoline raises levels of ergotamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Caution when CYP3A substrates which have a slim therapeutic index are coadministered with eluxadoline.
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elranatamab will enhance the level or outcome of ergotamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Elranatamab leads to cytokine launch syndrome (CRS) that may suppress activity of CYP enzymes, leading to enhanced exposure of CYP substrates.
Nirmatrelvir/ritonavir is contraindicated with medications that happen to read more be remarkably dependent on CYP3A for clearance and for which elevated concentrations are linked to major and/or everyday living-threatening reactions.