ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) will improve the level or impact of ergotamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Acute ergot toxicity characterised by vasospasm and tissue ischemia has been connected with coadministration of ritonavirdronedarone will boost the degree or result of ergota